Mus musculus Protein: Plch2 | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Protein | IDBP-538492.4 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | Plch2 | ||||||||||||||
Protein Name | phospholipase C, eta 2 | ||||||||||||||
Synonyms | |||||||||||||||
Species | Mus musculus | ||||||||||||||
Ensembl Protein | ENSMUSP00000118292 | ||||||||||||||
InnateDB Gene | IDBG-207301 (Plch2) | ||||||||||||||
Protein Structure | |||||||||||||||
UniProt Annotation | |||||||||||||||
Function | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain. {ECO:0000269PubMed:15899900, ECO:0000269PubMed:16107206}. | ||||||||||||||
Subcellular Localization | Cytoplasm {ECO:0000269PubMed:15899900}. Cell membrane {ECO:0000269PubMed:15899900}. Note=Localized predominantly at the plasma membrane. | ||||||||||||||
Disease Associations | |||||||||||||||
Tissue Specificity | Specifically detected in the brain, with higher level in cerebral cortex, olfactory bulb and hippocampus (at protein level). Expressed in the pyramidal cells of the hippocampus, but also in eye and lung. {ECO:0000269PubMed:15899900, ECO:0000269PubMed:16107206}. | ||||||||||||||
Comments | |||||||||||||||
Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||
PDB ID | MGI:2443078 | ||||||||||||||
InterPro |
IPR000008
C2 domain IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain IPR001192 Phosphoinositide phospholipase C family IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain IPR001849 Pleckstrin homology domain IPR002048 EF-hand domain IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain |
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PFAM |
PF00168
PF00388 PF00387 PF00169 PF00036 PF13202 PF13405 PF09279 |
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PRINTS |
PR00360
PR00390 |
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PIRSF | |||||||||||||||
SMART |
SM00239
SM00148 SM00149 SM00233 SM00054 |
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TIGRFAMs | |||||||||||||||
Post-translational Modifications | |||||||||||||||
Modification | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | A2AP18 | ||||||||||||||
PhosphoSite | PhosphoSite-A2AP18 | ||||||||||||||
TrEMBL | |||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 269615 | ||||||||||||||
UniGene | Mm.379458 | ||||||||||||||
RefSeq | |||||||||||||||
MGI ID | |||||||||||||||
MGI Symbol | Plch2 | ||||||||||||||
OMIM | |||||||||||||||
CCDS | |||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
EMBL | AK044619 AK049970 AK078731 AL831788 AY966876 BC040465 BC052329 BX004788 DQ176851 | ||||||||||||||
GenPept | AAH40465 AAH52329 AAY33831 ABA12210 BAC32005 BAC34011 BAC37371 CAM16344 CAM28037 CAO78007 CAO78129 | ||||||||||||||