InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UMPS

Summary

InnateDB Protein

IDBP-53860.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UMPS

Protein Name

uridine monophosphate synthetase

Synonyms

OPRT;

Species

Homo sapiens

Ensembl Protein

ENSP00000232607

InnateDB Gene

IDBG-53858 (UMPS)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Orotic aciduria 1 (ORAC1) [MIM:258900]: A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies. {ECO:0000269PubMed:9042911}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	16 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004588	orotate phosphoribosyltransferase activity
GO:0004590	orotidine-5'-phosphate decarboxylase activity

Biological Process

GO:0006206	pyrimidine nucleobase metabolic process
GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process
GO:0006222	UMP biosynthetic process
GO:0007565	female pregnancy
GO:0007595	lactation
GO:0008152	metabolic process
GO:0009116	nucleoside metabolic process
GO:0035690	cellular response to drug
GO:0044205	'de novo' UMP biosynthetic process
GO:0044281	small molecule metabolic process
GO:0046134	pyrimidine nucleoside biosynthetic process
GO:0055086	nucleobase-containing small molecule metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000836 Phosphoribosyltransferase domain
IPR001754 Orotidine 5\'-phosphate decarboxylase domain
IPR004467 Orotate phosphoribosyl transferase domain
IPR011060 Ribulose-phosphate binding barrel
IPR014732 Orotidine 5\'-phosphate decarboxylase
IPR029057 Phosphoribosyltransferase-like

PFAM

PF00156
PF00215

PRINTS

PIRSF

SMART

SM00934

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P11172