InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Myo5a

Summary

InnateDB Protein

IDBP-538601.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Myo5a

Protein Name

myosin VA

Synonyms

9630007J19Rik; AI413174; AI661011; d; d-120J; Dbv; flail; flr; MVa; Myo5; MyoVA; Sev-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000117493

InnateDB Gene

IDBG-184743 (Myo5a)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000146	microfilament motor activity
GO:0003774	motor activity
GO:0003779	actin binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006582	melanin metabolic process
GO:0006887	exocytosis
GO:0007268	synaptic transmission
GO:0007601	visual perception
GO:0030048	actin filament-based movement
GO:0030050	vesicle transport along actin filament
GO:0030073	insulin secretion
GO:0030318	melanocyte differentiation
GO:0031585	regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0031987	locomotion involved in locomotory behavior
GO:0032252	secretory granule localization
GO:0032400	melanosome localization
GO:0032402	melanosome transport
GO:0042438	melanin biosynthetic process
GO:0042476	odontogenesis
GO:0042552	myelination
GO:0042640	anagen
GO:0042759	long-chain fatty acid biosynthetic process
GO:0043473	pigmentation
GO:0048066	developmental pigmentation
GO:0050808	synapse organization
GO:0051643	endoplasmic reticulum localization

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005882	intermediate filament
GO:0016459	myosin complex
GO:0030141	secretory granule
GO:0035371	microtubule plus-end
GO:0042470	melanosome
GO:0042641	actomyosin
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

MGI:105976

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR001609 Myosin head, motor domain
IPR002710 Dilute
IPR016072 SKP1 component, dimerisation
IPR018444 Dil domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00612
PF00063
PF01466
PF01843

PRINTS

PR00193

PIRSF

SMART

SM00015
SM00242

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt