InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Myo5a

Summary

InnateDB Gene

IDBG-184743.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Myo5a

Gene Name

myosin VA

Synonyms

9630007J19Rik; AI413174; AI661011; d; d-120J; Dbv; flail; flr; MVa; Myo5; MyoVA; Sev-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000034593

Encoded Proteins

IDBP-532111

myosin VA

IDBP-538601

myosin VA

IDBP-540324

myosin VA

IDBP-541877

myosin VA

IDBP-534369

myosin VA

IDBP-532417

myosin VA

IDBP-532076

myosin VA

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197535:
This gene is one of three myosin V heavy-chain genes, belonging to the myosin gene superfamily. Myosin V is a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation. The protein encoded by this gene is abundant in melanocytes and nerve cells. Mutations in this gene cause Griscelli syndrome type-1 (GS1), Griscelli syndrome type-3 (GS3) and neuroectodermal melanolysosomal disease, or Elejalde disease. Multiple alternatively spliced transcript variants encoding different isoforms have been reported, but the full-length nature of some variants has not been determined. [provided by RefSeq, Dec 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:75071015-75223688

Strand

Forward strand

Band

Transcripts

ENSMUST00000149823
ENSMUST00000123128	ENSMUSP00000116028
ENSMUST00000155282	ENSMUSP00000117493
ENSMUST00000136871
ENSMUST00000123531	ENSMUSP00000122773
ENSMUST00000136731	ENSMUSP00000120444
ENSMUST00000142181
ENSMUST00000136604
ENSMUST00000149032
ENSMUST00000129281	ENSMUSP00000118881
ENSMUST00000148144	ENSMUSP00000121158
ENSMUST00000130384	ENSMUSP00000114803
ENSMUST00000143355
ENSMUST00000153404

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000146	microfilament motor activity
GO:0003774	motor activity
GO:0003779	actin binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0017137	Rab GTPase binding
GO:0044822	poly(A) RNA binding
GO:0051015	actin filament binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006582	melanin metabolic process
GO:0006887	exocytosis
GO:0007268	synaptic transmission
GO:0007601	visual perception
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0030048	actin filament-based movement
GO:0030050	vesicle transport along actin filament
GO:0030073	insulin secretion
GO:0030318	melanocyte differentiation
GO:0031585	regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0031987	locomotion involved in locomotory behavior
GO:0032252	secretory granule localization
GO:0032400	melanosome localization
GO:0032402	melanosome transport
GO:0032869	cellular response to insulin stimulus
GO:0042438	melanin biosynthetic process
GO:0042476	odontogenesis
GO:0042552	myelination
GO:0042640	anagen
GO:0042759	long-chain fatty acid biosynthetic process
GO:0043473	pigmentation
GO:0048066	developmental pigmentation
GO:0050808	synapse organization
GO:0051643	endoplasmic reticulum localization
GO:0072659	protein localization to plasma membrane

Cellular Component

GO:0001726	ruffle
GO:0001750	photoreceptor outer segment
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005882	intermediate filament
GO:0016020	membrane
GO:0016459	myosin complex
GO:0030141	secretory granule
GO:0032593	insulin-responsive compartment
GO:0035371	microtubule plus-end
GO:0042470	melanosome
GO:0042641	actomyosin
GO:0043025	neuronal cell body