InnateDB Protein
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IDBP-538622.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Dnmt3l
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Protein Name
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DNA (cytosine-5-)-methyltransferase 3-like
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Synonyms
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D6Ertd14e; ecat7;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000116970
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InnateDB Gene
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IDBG-168381 (Dnmt3l)
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Protein Structure
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Function |
Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. {ECO:0000269PubMed:11719692, ECO:0000269PubMed:15671018}.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Expressed in testis, thymus, ovary, and heart.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
20
[view]
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Protein-Protein |
18
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
6 [view]
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|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1859287
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InterPro |
IPR011011
Zinc finger, FYVE/PHD-type
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9CWR8
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PhosphoSite |
PhosphoSite-Q9CWR8
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TrEMBL |
D3YUQ4
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UniProt Splice Variant |
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Entrez Gene |
54427
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UniGene |
Mm.13433
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RefSeq |
NP_001271126
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MGI ID |
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MGI Symbol |
Dnmt3l
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OMIM |
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CCDS |
CCDS23962
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HPRD |
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IMGT |
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EMBL |
AC153507
AF220524
AJ404467
AK010434
BC083147
CH466553
EF051624
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GenPept |
AAF73868
AAH83147
ABN46989
BAB26936
CAB94726
EDL31749
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