InnateDB Protein
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IDBP-538761.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Polr3c
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Protein Name
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polymerase (RNA) III (DNA directed) polypeptide C
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Synonyms
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4933407E01Rik; RPC3; RPC62;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000122435
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InnateDB Gene
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IDBG-176295 (Polr3c)
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Protein Structure
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Function |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB- DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
22 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
GO:0005666
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DNA-directed RNA polymerase III complex
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PDB ID |
MGI:1921664
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InterPro |
IPR008806
RNA polymerase III Rpc82, C -terminal
IPR013197
RNA polymerase III subunit RPC82-related, helix-turn-helix
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PFAM |
PF05645
PF08221
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9D483
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PhosphoSite |
PhosphoSite-Q9D483
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TrEMBL |
B2RX77
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UniProt Splice Variant |
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Entrez Gene |
74414
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UniGene |
Mm.404180
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RefSeq |
XP_006502250
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MGI ID |
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MGI Symbol |
Polr3c
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OMIM |
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CCDS |
CCDS51010
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HPRD |
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IMGT |
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EMBL |
AK016716
BC026793
BC147485
BC151028
CH466620
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GenPept |
AAH26793
AAI47486
AAI51029
BAB30395
EDL38917
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