Mus musculus Protein: Ptgr2
Summary
InnateDB Protein IDBP-538791.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ptgr2
Protein Name prostaglandin reductase 2
Synonyms 1810016I24Rik; 9130222H03Rik; 9630002F03Rik; AI838763; B830026H24Rik; PGR-2; PRG-2; Zadh1;
Species Mus musculus
Ensembl Protein ENSMUSP00000115704
InnateDB Gene IDBG-156341 (Ptgr2)
Protein Structure
UniProt Annotation
Function Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto- PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation. {ECO:0000269PubMed:17449869}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed with highest levels in adipose tissues. {ECO:0000269PubMed:17449869}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0036132 13-prostaglandin reductase activity
GO:0047522 15-oxoprostaglandin 13-oxidase activity
Biological Process
GO:0006693 prostaglandin metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol
Protein Structure and Domains
PDB ID MGI:1916372
InterPro IPR011032 GroES (chaperonin 10)-like
IPR013149 Alcohol dehydrogenase, C-terminal
PFAM PF00107
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8VDQ1
PhosphoSite PhosphoSite-Q8VDQ1
TrEMBL
UniProt Splice Variant
Entrez Gene 77219
UniGene Mm.475248
RefSeq NP_084156
MGI ID 2ZB3
MGI Symbol Ptgr2
OMIM
CCDS CCDS36490
HPRD
IMGT
EMBL AK021033 AK036168 AK145232 AK159932 AK168895 BC021466
GenPept AAH21466 BAB32284 BAC29329 BAE26315 BAE35493 BAE40712