Version 5.4
Mus musculus Gene: Ptgr2
Summary
InnateDB Gene IDBG-156341.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ptgr2
Gene Name prostaglandin reductase 2
Synonyms 1810016I24Rik; 9130222H03Rik; 9630002F03Rik; AI838763; B830026H24Rik; PGR-2; PRG-2; Zadh1
Species Mus musculus
Ensembl Gene ENSMUSG00000072946
Encoded Proteins
IDBP-538791
prostaglandin reductase 2
IDBP-539258
prostaglandin reductase 2
IDBP-535776
prostaglandin reductase 2
IDBP-539352
prostaglandin reductase 2
IDBP-536683
prostaglandin reductase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140043:
This gene encodes an enzyme involved in the metabolism of prostaglandins. The encoded protein catalyzes the NADPH-dependent conversion of 15-keto-prostaglandin E2 to 15-keto-13,14-dihydro-prostaglandin E2. This protein may also be involved in regulating activation of the peroxisome proliferator-activated receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:84285232-84315832
Strand Forward strand
Band D1
Transcripts
ENSMUST00000123614 ENSMUSP00000115704
ENSMUST00000138733
ENSMUST00000147363 ENSMUSP00000114766
ENSMUST00000128158
ENSMUST00000128541
ENSMUST00000150720
ENSMUST00000135001 ENSMUSP00000114559
ENSMUST00000146377 ENSMUSP00000119981
ENSMUST00000123693 ENSMUSP00000115506
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0036132 13-prostaglandin reductase activity
GO:0047522 15-oxoprostaglandin 13-oxidase activity
Biological Process
GO:0006693 prostaglandin metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000140043
View Gene Order
ENSBTAG00000003747
Not yet available
Pathways
NETPATH
REACTOME
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_188623
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) pathway
REACT_188625
Arachidonic acid metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.403204 Mm.475248
RefSeq NM_001252625 NM_001252626 NM_029880
OMIM
CCDS CCDS36490
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca