InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gnao1

Summary

InnateDB Protein

IDBP-538807.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gnao1

Protein Name

guanine nucleotide binding protein, alpha O

Synonyms

alphaO; AW050213; Galphao; Gnao;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000118463

InnateDB Gene

IDBG-181138 (Gnao1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005525	GTP binding
GO:0019001	guanyl nucleotide binding
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0031821	G-protein coupled serotonin receptor binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007212	dopamine receptor signaling pathway
GO:0007626	locomotory behavior
GO:0008016	regulation of heart contraction
GO:0009987	cellular process

Cellular Component

GO:0005622	intracellular
GO:0005834	heterotrimeric G-protein complex
GO:0016020	membrane
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane

Protein Structure and Domains

PDB ID

MGI:95775

InterPro

IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
IPR001408 G-protein alpha subunit, group I
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00503

PRINTS

PR00318
PR00441

PIRSF

SMART

SM00275

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

F6WC15

UniProt Splice Variant

Entrez Gene

14681

UniGene

Mm.487013

RefSeq

MGI ID

MGI Symbol

Gnao1

OMIM

CCDS

HPRD

IMGT

EMBL

AC102398 AC138118

GenPept