InnateDB Protein
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IDBP-538811.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Stau2
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Protein Name
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staufen (RNA binding protein) homolog 2 (Drosophila)
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000125726
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InnateDB Gene
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IDBG-135149 (Stau2)
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Protein Structure
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Function |
RNA-binding protein required for the microtubule- dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:15166236}. Nucleus {ECO:0000269PubMed:15166236}. Nucleus, nucleolus {ECO:0000269PubMed:15166236}. Endoplasmic reticulum {ECO:0000269PubMed:15166236}. Note=Shuttles between the nucleolus, nucleus and the cytoplasm. Nuclear export of isoform 1 is independent of XPO1/CRM1 and requires the exportin XPO5. Nuclear export of isoform 2 and isoform 3 can occur by both XPO1/CRM1-dependent and XPO1/CRM1-independent pathways. May also be found in large cytoplasmic ribonucleoprotein (RNP) granules which are present in the actin rich regions of myelinating processes and associated with microtubules, polysomes and the endoplasmic reticulum. Also recruited to stress granules (SGs) upon inhibition of translation or oxidative stress. These structures are thought to harbor housekeeping mRNAs when translation is aborted.
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Disease Associations |
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Tissue Specificity |
Expressed in brain and neurons, where isoform 2 and isoform 3 appear to be the most abundant. Expressed at the neuromuscular junction of the extensor digitorum longus, tibialis anterior and soleus muscles. Expression at neuromuscular junctions is most pronounced in slow-twitch muscle. Also weakly expressed in heart, kidney, ovary and testis. {ECO:0000269PubMed:12140260, ECO:0000269PubMed:12859680}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
7 [view]
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Molecular Function |
Accession |
GO Term |
GO:0003725
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double-stranded RNA binding
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1352508
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InterPro |
IPR014720
Double-stranded RNA-binding domain
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PFAM |
PF00035
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PRINTS |
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PIRSF |
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SMART |
SM00358
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TIGRFAMs |
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Modification |
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SwissProt |
Q8CJ67
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PhosphoSite |
PhosphoSite-Q8CJ67
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TrEMBL |
E2QRQ3
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UniProt Splice Variant |
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Entrez Gene |
29819
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UniGene |
Mm.401175
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RefSeq |
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MGI ID |
1UHZ
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MGI Symbol |
Stau2
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AC115952
AC116695
AC162448
AC167117
AF459099
AF459100
AK015087
AK028390
BC010300
BC025118
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GenPept |
AAH10300
AAH25118
AAN37928
AAN37929
BAB29708
BAC25926
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