InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sf1

Summary

InnateDB Protein

IDBP-538818.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sf1

Protein Name

splicing factor 1

Synonyms

BBP; MZFM; WBP4; Zfp162;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000121309

InnateDB Gene

IDBG-136142 (Sf1)

Protein Structure

UniProt Annotation

Function

Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Detected at intermediate levels in spleen. Lower levels in heart, kidney, brain, liver, testis, bone marrow, adrenal gland, lymph nodes, pancreas and thymus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 62 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	24 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	62 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0008270	zinc ion binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0030238	male sex determination
GO:0033327	Leydig cell differentiation
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0050810	regulation of steroid biosynthetic process