InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sri

Summary

InnateDB Protein

IDBP-538888.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sri

Protein Name

sorcin

Synonyms

2210417O06Rik; 2900070H08Rik; Sor;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000118221

InnateDB Gene

IDBG-133148 (Sri)

Protein Structure

UniProt Annotation

Function

Calcium-binding protein that modulates excitation- contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels. {ECO:0000269PubMed:12824171}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12824171}. Sarcoplasmic reticulum membrane {ECO:0000269PubMed:12824171}; Peripheral membrane protein {ECO:0000269PubMed:12824171}; Cytoplasmic side {ECO:0000269PubMed:12824171}. Note=Relocates to the sarcoplasmic reticulum membrane in response to elevated calcium levels.

Disease Associations

Tissue Specificity

Detected in cardiac myocytes. {ECO:0000269PubMed:12824171}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004198	calcium-dependent cysteine-type endopeptidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity
GO:0070491	repressing transcription factor binding

Biological Process

GO:0006508	proteolysis
GO:0006816	calcium ion transport
GO:0007507	heart development
GO:0010459	negative regulation of heart rate
GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0042994	cytoplasmic sequestering of transcription factor
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
GO:0051924	regulation of calcium ion transport
GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0086004	regulation of cardiac muscle cell contraction
GO:1901077	regulation of relaxation of muscle
GO:1901841	regulation of high voltage-gated calcium channel activity
GO:1901844	regulation of cell communication by electrical coupling involved in cardiac conduction
GO:2000678	negative regulation of transcription regulatory region DNA binding

Cellular Component

GO:0005622	intracellular
GO:0005739	mitochondrion
GO:0005789	endoplasmic reticulum membrane
GO:0005790	smooth endoplasmic reticulum
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030018	Z disc
GO:0030315	T-tubule
GO:0030424	axon
GO:0031982	vesicle
GO:0033017	sarcoplasmic reticulum membrane
GO:0042584	chromaffin granule membrane
GO:0043679	axon terminus
GO:0044326	dendritic spine neck
GO:0070062	extracellular vesicular exosome