Version 5.4
Mus musculus Gene: Sri
Summary
InnateDB Gene IDBG-133148.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sri
Gene Name sorcin
Synonyms 2210417O06Rik; 2900070H08Rik; Sor
Species Mus musculus
Ensembl Gene ENSMUSG00000003161
Encoded Proteins
IDBP-133150
sorcin
IDBP-538888
sorcin
IDBP-538122
sorcin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000075142:
This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:8046078-8069379
Strand Forward strand
Band A1
Transcripts
ENSMUST00000088786 ENSMUSP00000086165
ENSMUST00000003245
ENSMUST00000148633 ENSMUSP00000118221
ENSMUST00000145119
ENSMUST00000144265
ENSMUST00000149420 ENSMUSP00000121194
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0046982 protein heterodimerization activity
GO:0070491 repressing transcription factor binding
Biological Process
GO:0006508 proteolysis
GO:0006816 calcium ion transport
GO:0007507 heart development
GO:0010459 negative regulation of heart rate
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0042994 cytoplasmic sequestering of transcription factor
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051924 regulation of calcium ion transport
GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0086004 regulation of cardiac muscle cell contraction
GO:1901077 regulation of relaxation of muscle
GO:1901841 regulation of high voltage-gated calcium channel activity
GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction
GO:2000678 negative regulation of transcription regulatory region DNA binding
Cellular Component
GO:0005622 intracellular
GO:0005739 mitochondrion
GO:0005789 endoplasmic reticulum membrane
GO:0005790 smooth endoplasmic reticulum
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030018 Z disc
GO:0030315 T-tubule
GO:0030424 axon
GO:0031982 vesicle
GO:0033017 sarcoplasmic reticulum membrane
GO:0042584 chromaffin granule membrane
GO:0043679 axon terminus
GO:0044326 dendritic spine neck
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000075142
View Gene Order
ENSBTAG00000010390
Not yet available
Pathways
NETPATH
REACTOME
REACT_196640
Stimuli-sensing channels pathway
REACT_262350
Ion channel transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q6P069
TrEMBL
UniProt Splice Variant
Entrez Gene 109552
UniGene Mm.96211
RefSeq NM_001080974 NM_025618 XM_006503526
OMIM
CCDS CCDS39009 CCDS19079
HPRD
IMGT
MGI ID MGI:98419
MGI Symbol Sri
EMBL AK008404 AK008783 AK008970 AK134747 AK146071 AK146911 AK168572 AK168792 AK168900 BC065790
GenPept AAH65790 BAB25652 BAB25891 BAB25997 BAE22266 BAE26876 BAE27523 BAE40442 BAE40625 BAE40716
RNA Seq Atlas 109552

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca