InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tyrp1

Summary

InnateDB Protein

IDBP-538897.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tyrp1

Protein Name

tyrosinase-related protein 1

Synonyms

b; brown; isa; Oca3; TRP-1; TRP1; Tyrp;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000117080

InnateDB Gene

IDBG-159178 (Tyrp1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005507	copper ion binding
GO:0016491	oxidoreductase activity
GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen

Biological Process

GO:0006582	melanin metabolic process
GO:0008152	metabolic process
GO:0030318	melanocyte differentiation
GO:0032438	melanosome organization
GO:0042438	melanin biosynthetic process
GO:0043438	acetoacetic acid metabolic process
GO:0043473	pigmentation
GO:0055114	oxidation-reduction process

Cellular Component

GO:0010008	endosome membrane
GO:0030669	clathrin-coated endocytic vesicle membrane
GO:0033162	melanosome membrane
GO:0042470	melanosome

Protein Structure and Domains

PDB ID

MGI:98881

InterPro

IPR002227 Tyrosinase copper-binding domain
IPR008922 Uncharacterised domain, di-copper centre

PFAM

PF00264

PRINTS

PR00092

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

A2ADJ4

UniProt Splice Variant

Entrez Gene

22178

UniGene

Mm.412291

RefSeq

MGI ID

MGI Symbol

Tyrp1

OMIM

CCDS

HPRD

IMGT

EMBL

AL670884

GenPept

CAM22449