InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ifnar1

Summary

InnateDB Protein

IDBP-538950.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ifnar1

Protein Name

interferon (alpha and beta) receptor 1

Synonyms

CD118; Ifar; Ifnar; Ifrc; Infar;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000119160

InnateDB Gene

IDBG-176038 (Ifnar1)

Protein Structure

UniProt Annotation

Function

Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta- subunits themselves. Can also transduce IFNB signals without the help of IFNAR2, and not activating the Jak-STAT pathway. {ECO:0000269PubMed:23872679}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004904	interferon receptor activity
GO:0005515	protein binding

Biological Process

GO:0019221	cytokine-mediated signaling pathway
GO:0032729	positive regulation of interferon-gamma production
GO:0042110	T cell activation
GO:0045087	innate immune response (InnateDB)
GO:0045351	type I interferon biosynthetic process
GO:0050718	positive regulation of interleukin-1 beta secretion
GO:0051607	defense response to virus