InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Apoc2

Summary

InnateDB Protein

IDBP-538992.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Apoc2

Protein Name

apolipoprotein C-II

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000114512

InnateDB Gene

IDBG-151996 (Apoc2)

Protein Structure

UniProt Annotation

Function

Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Secreted in plasma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008047	enzyme activator activity
GO:0008289	lipid binding
GO:0016004	phospholipase activator activity
GO:0042803	protein homodimerization activity
GO:0043274	phospholipase binding
GO:0055102	lipase inhibitor activity
GO:0060230	lipoprotein lipase activator activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006869	lipid transport
GO:0010518	positive regulation of phospholipase activity
GO:0010898	positive regulation of triglyceride catabolic process
GO:0010916	negative regulation of very-low-density lipoprotein particle clearance
GO:0016042	lipid catabolic process
GO:0032375	negative regulation of cholesterol transport
GO:0033344	cholesterol efflux
GO:0033700	phospholipid efflux
GO:0034382	chylomicron remnant clearance
GO:0034384	high-density lipoprotein particle clearance
GO:0042493	response to drug
GO:0042953	lipoprotein transport
GO:0043086	negative regulation of catalytic activity
GO:0045723	positive regulation of fatty acid biosynthetic process
GO:0045833	negative regulation of lipid metabolic process
GO:0048261	negative regulation of receptor-mediated endocytosis
GO:0051006	positive regulation of lipoprotein lipase activity
GO:0060697	positive regulation of phospholipid catabolic process
GO:0070328	triglyceride homeostasis

Cellular Component

GO:0005576	extracellular region
GO:0005829	cytosol
GO:0034361	very-low-density lipoprotein particle
GO:0034362	low-density lipoprotein particle
GO:0034363	intermediate-density lipoprotein particle
GO:0034366	spherical high-density lipoprotein particle
GO:0042627	chylomicron