InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Apoc2

Summary

InnateDB Gene

IDBG-151996.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Apoc2

Gene Name

apolipoprotein C-II

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000002992

Encoded Proteins

IDBP-151998

apolipoprotein C-II

IDBP-535352

apolipoprotein C-II

IDBP-535185

apolipoprotein C-II

IDBP-538992

apolipoprotein C-II

IDBP-532974

apolipoprotein C-II

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000224916:
This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is thought to play a role in lipid metabolism. Polymorphisms in this gene may influence circulating lipid levels and may be associated with coronary artery disease risk. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring downstream apolipoprotein C-II (APOC2) gene. [provided by RefSeq, Mar 2011] This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene. [provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:19671579-19681423

Strand

Reverse strand

Band

Transcripts

ENSMUST00000003074	ENSMUSP00000003074
ENSMUST00000142352	ENSMUSP00000115173
ENSMUST00000134116	ENSMUSP00000118291
ENSMUST00000150569	ENSMUSP00000114512
ENSMUST00000127648	ENSMUSP00000118305

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008047	enzyme activator activity
GO:0008289	lipid binding
GO:0016004	phospholipase activator activity
GO:0042803	protein homodimerization activity
GO:0043274	phospholipase binding
GO:0055102	lipase inhibitor activity
GO:0060230	lipoprotein lipase activator activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006869	lipid transport
GO:0010518	positive regulation of phospholipase activity
GO:0010898	positive regulation of triglyceride catabolic process
GO:0010916	negative regulation of very-low-density lipoprotein particle clearance
GO:0016042	lipid catabolic process
GO:0032375	negative regulation of cholesterol transport
GO:0033344	cholesterol efflux
GO:0033700	phospholipid efflux
GO:0034382	chylomicron remnant clearance
GO:0034384	high-density lipoprotein particle clearance
GO:0042493	response to drug
GO:0042953	lipoprotein transport
GO:0043086	negative regulation of catalytic activity
GO:0045723	positive regulation of fatty acid biosynthetic process
GO:0045833	negative regulation of lipid metabolic process
GO:0048261	negative regulation of receptor-mediated endocytosis
GO:0051006	positive regulation of lipoprotein lipase activity
GO:0060697	positive regulation of phospholipid catabolic process
GO:0070328	triglyceride homeostasis

Cellular Component

GO:0005576	extracellular region
GO:0005829	cytosol
GO:0034361	very-low-density lipoprotein particle
GO:0034362	low-density lipoprotein particle
GO:0034363	intermediate-density lipoprotein particle
GO:0034366	spherical high-density lipoprotein particle
GO:0042627	chylomicron