InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sphk1

Summary

InnateDB Protein

IDBP-539041.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sphk1

Protein Name

sphingosine kinase 1

Synonyms

1110006G24Rik; Sk1; Spk1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000116055

InnateDB Gene

IDBG-214470 (Sphk1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	2 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003951	NAD+ kinase activity
GO:0004143	diacylglycerol kinase activity
GO:0005516	calmodulin binding
GO:0008481	sphinganine kinase activity

Biological Process

GO:0001568	blood vessel development
GO:0006954	inflammatory response
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007420	brain development
GO:0008284	positive regulation of cell proliferation
GO:0032651	regulation of interleukin-1 beta production
GO:0046834	lipid phosphorylation

Cellular Component

Protein Structure and Domains

PDB ID

MGI:1316649

InterPro

IPR001206 Diacylglycerol kinase, catalytic domain

PFAM

PF00781

PRINTS

PIRSF

SMART

SM00046

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

B1AT86

UniProt Splice Variant

Entrez Gene

20698

UniGene

Mm.402539

RefSeq

MGI ID

MGI Symbol

Sphk1

OMIM

CCDS

HPRD

IMGT

EMBL

AL645851

GenPept