InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sphk1

Summary

InnateDB Gene

IDBG-214470.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sphk1

Gene Name

sphingosine kinase 1

Synonyms

1110006G24Rik; Sk1; Spk1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000061878

Encoded Proteins

IDBP-214472

sphingosine kinase 1

IDBP-214474

sphingosine kinase 1

IDBP-214476

sphingosine kinase 1

IDBP-268868

sphingosine kinase 1

IDBP-268870

sphingosine kinase 1

IDBP-268872

sphingosine kinase 1

IDBP-541046

sphingosine kinase 1

IDBP-535309

sphingosine kinase 1

IDBP-533372

sphingosine kinase 1

IDBP-541576

sphingosine kinase 1

IDBP-539041

sphingosine kinase 1

IDBP-623187

sphingosine kinase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20634980

[Homo sapiens] SPHK1 is involved in toll-mediated human beta-defensin 2 (HBD-2) regulation in oral keratinocytes, which also involves the activation of PI3K, AKT, GSK3B (GSK-3beta) and ERK 1/2.

PMID 20661259

[Homo sapiens] SPHK1 activation, mediated by TLR4, is found to be critical for the redox-dependent activation of HIF-1alpha and ASK1, as well as for the prevention of LPS-induced activation of caspase 3 and the expression of pro-inflammatory cytokine interleukin-6.

PMID 26113114

[Homo sapiens] (S)-methyl 2-(hexanamide)-3-(4-hydroxyphenyl) propanoate (MHP) activates SPHK1, which also stimulates CAMP production and enhances epidermal antimicrobial defence.

Entrez Gene

Summary

This gene encodes a kinase that phosphorylates sphingosine into sphingosine-1-phosphate, which is involved in cell differentiation, motility, and apoptosis. The encoded protein plays a role in maintaining cellular levels of sphingosine-1-phosphate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:116530925-116536674

Strand

Forward strand

Band

Transcripts

ENSMUST00000100201	ENSMUSP00000097775
ENSMUST00000063396	ENSMUSP00000064743
ENSMUST00000063446	ENSMUSP00000067865
ENSMUST00000106388	ENSMUSP00000101996
ENSMUST00000106387	ENSMUSP00000101995
ENSMUST00000106386	ENSMUSP00000101994
ENSMUST00000138840	ENSMUSP00000121064
ENSMUST00000136526
ENSMUST00000134834
ENSMUST00000145737	ENSMUSP00000114622
ENSMUST00000155102	ENSMUSP00000114819
ENSMUST00000150658
ENSMUST00000154034	ENSMUSP00000121219
ENSMUST00000124682	ENSMUSP00000116055
ENSMUST00000148185
ENSMUST00000141798	ENSMUSP00000131010

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	2 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003677	DNA binding
GO:0003951	NAD+ kinase activity
GO:0004143	diacylglycerol kinase activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0008481	sphinganine kinase activity
GO:0017050	D-erythro-sphingosine kinase activity
GO:0051721	protein phosphatase 2A binding

Biological Process

GO:0001568	blood vessel development
GO:0001934	positive regulation of protein phosphorylation
GO:0001956	positive regulation of neurotransmitter secretion
GO:0006670	sphingosine metabolic process
GO:0006954	inflammatory response
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007420	brain development
GO:0007565	female pregnancy
GO:0008284	positive regulation of cell proliferation
GO:0009267	cellular response to starvation
GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway
GO:0010976	positive regulation of neuron projection development
GO:0014070	response to organic cyclic compound
GO:0014075	response to amine
GO:0019371	cyclooxygenase pathway
GO:0019722	calcium-mediated signaling
GO:0030307	positive regulation of cell growth
GO:0030335	positive regulation of cell migration
GO:0031398	positive regulation of protein ubiquitination
GO:0032026	response to magnesium ion
GO:0032570	response to progesterone
GO:0032651	regulation of interleukin-1 beta production
GO:0033198	response to ATP
GO:0042346	positive regulation of NF-kappaB import into nucleus
GO:0043066	negative regulation of apoptotic process
GO:0045766	positive regulation of angiogenesis
GO:0045931	positive regulation of mitotic cell cycle
GO:0045987	positive regulation of smooth muscle contraction
GO:0046834	lipid phosphorylation
GO:0048146	positive regulation of fibroblast proliferation
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0070301	cellular response to hydrogen peroxide
GO:0070555	response to interleukin-1
GO:0071363	cellular response to growth factor stimulus