InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ITGA2B

Summary

InnateDB Protein

IDBP-53912.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGA2B

Protein Name

integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)

Synonyms

BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb; GT; GTA; HPA3; PPP1R93;

Species

Homo sapiens

Ensembl Protein

ENSP00000262407

InnateDB Gene

IDBG-53910 (ITGA2B)

Protein Structure

UniProt Annotation

Function

Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Glanzmann thrombasthenia (GT) [MIM:273800]: A common inherited disease of platelet aggregation. It is characterized by mucocutaneous bleeding of mild-to-moderate severity. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb-IIIa complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the GPIIb-IIIa complex at reduced levels, have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. {ECO:0000269PubMed:10607701, ECO:0000269PubMed:11798398, ECO:0000269PubMed:12083483, ECO:0000269PubMed:12181054, ECO:0000269PubMed:12424194, ECO:0000269PubMed:12506038, ECO:0000269PubMed:15099289, ECO:0000269PubMed:15219201, ECO:0000269PubMed:17018384, ECO:0000269PubMed:20020534, ECO:0000269PubMed:7508443, ECO:0000269PubMed:7706461, ECO:0000269PubMed:8282784, ECO:0000269PubMed:8704171, ECO:0000269PubMed:9215749, ECO:0000269PubMed:9473221, ECO:0000269PubMed:9722314, ECO:0000269PubMed:9734640, ECO:0000269PubMed:9763559, ECO:0000269PubMed:9920835}. Note=The disease is caused by mutations affecting the gene represented in this entry.Bleeding disorder, platelet-type 16 (BDPLT16) [MIM:187800]: An autosomal dominant form of congenital macrothrombocytopenia associated with platelet anisocytosis. It is a disorder of platelet production. Affected individuals may have no or only mildly increased bleeding tendency. In vitro studies show mild platelet functional abnormalities. {ECO:0000269PubMed:21454453, ECO:0000269PubMed:9834222}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U-937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	17 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding
GO:0050840	extracellular matrix binding
GO:0070051	fibrinogen binding

Biological Process

GO:0002576	platelet degranulation
GO:0002687	positive regulation of leukocyte migration
GO:0007155	cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0030168	platelet activation
GO:0030198	extracellular matrix organization
GO:0070527	platelet aggregation

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005925	focal adhesion
GO:0008305	integrin complex
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0031092	platelet alpha granule membrane
GO:0072562	blood microparticle

Protein Structure and Domains

PDB ID

InterPro

IPR000413 Integrin alpha chain
IPR013517 FG-GAP repeat
IPR013519 Integrin alpha beta-propellor
IPR013649 Integrin alpha-2
IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site

PFAM

PF01839
PF14312
PF08441
PF00357

PRINTS

PR01185

PIRSF

SMART

SM00191

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt