Version 5.4
| Mus musculus Protein: Cldn16 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-539157.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Cldn16 | ||||||||
| Protein Name | claudin 16 | ||||||||
| Synonyms | claudin-16; PCLN1; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000124528 | ||||||||
| InnateDB Gene | IDBG-150417 (Cldn16) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:2148742 | ||||||||
| InterPro |
IPR003927
Claudin-16 IPR004031 PMP-22/EMP/MP20/Claudin superfamily IPR006187 Claudin |
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| PFAM |
PF00822
PF13903 |
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| PRINTS |
PR01447
PR01077 |
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| PIRSF | |||||||||
| SMART | |||||||||
| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q925N4 | ||||||||
| PhosphoSite | PhosphoSite-Q925N4 | ||||||||
| TrEMBL | Q14BW2 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 114141 | ||||||||
| UniGene | Mm.275205 | ||||||||
| RefSeq | NP_444471 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Cldn16 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS28088 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AB009016 AF323748 AK085268 AK085333 BC115574 BC115575 | ||||||||
| GenPept | AAI15575 AAI15576 AAK49518 BAC39406 BAC39425 BAF80617 | ||||||||