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InnateDB Protein
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IDBP-539180.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Gclm
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Protein Name
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glutamate-cysteine ligase, modifier subunit
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Synonyms
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AI649393; Gcmc; Glclr;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000123683
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InnateDB Gene
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IDBG-191550 (Gclm)
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Protein Structure
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| Function |
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| Subcellular Localization |
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
2
[view]
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| Protein-Protein |
2
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
14 [view]
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Molecular Function |
| Accession |
GO Term |
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GO:0035226
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glutamate-cysteine ligase catalytic subunit binding
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GO:0046982
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protein heterodimerization activity
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| Biological Process |
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GO:0006534
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cysteine metabolic process
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GO:0006749
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glutathione metabolic process
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GO:0006750
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glutathione biosynthetic process
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GO:0006979
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response to oxidative stress
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GO:0008637
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apoptotic mitochondrial changes
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GO:0035229
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positive regulation of glutamate-cysteine ligase activity
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GO:0051900
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regulation of mitochondrial depolarization
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GO:2001237
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negative regulation of extrinsic apoptotic signaling pathway
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| Cellular Component |
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| PDB ID |
MGI:104995
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| InterPro |
IPR023210
NADP-dependent oxidoreductase domain
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| PFAM |
PF00248
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-
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| TrEMBL |
F6VNW5
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| UniProt Splice Variant |
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| Entrez Gene |
14630
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| UniGene |
Mm.408068
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| RefSeq |
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| MGI ID |
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| MGI Symbol |
Gclm
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| OMIM |
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
AC134918
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| GenPept |
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Version 5.4