Version 5.4
Mus musculus Protein: Spnb2
Summary
InnateDB Protein IDBP-539186.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Spnb2
Protein Name spectrin beta 2
Synonyms 9930031C03Rik; AL033301; elf1; elf3; mKIAA4049; Spnb-2; Spnb2; SPTB2;
Species Mus musculus
Ensembl Protein ENSMUSP00000114841
InnateDB Gene IDBG-158171 (Spnb2)
Protein Structure
UniProt Annotation
Function Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000269PubMed:9927192}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000269PubMed:9927192}. Note=Colocalizes with ANK2 in a distinct intracellular compartment of neonatal cardiomyocytes.Isoform 2: Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Disease Associations
Tissue Specificity Isoform 2 is present in brain, heart, kidney and liver (at protein level). {ECO:0000269PubMed:15262991, ECO:0000269PubMed:9927192}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 84 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 26 [view]
Protein-DNA 2 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 84 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0008091 spectrin
Protein Structure and Domains
PDB ID MGI:98388
InterPro IPR001715 Calponin homology domain
IPR002017 Spectrin repeat
IPR016343 Spectrin, beta subunit
IPR018159 Spectrin/alpha-actinin
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domain
PFAM PF00307
PF00435
PF11971
PRINTS
PIRSF PIRSF002297
SMART SM00033
SM00150
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-Q62261
TrEMBL P70435
UniProt Splice Variant
Entrez Gene 20742
UniGene Mm.458963
RefSeq
MGI ID
MGI Symbol Sptbn1
OMIM
CCDS
HPRD
IMGT
EMBL U73171
GenPept AAB18135

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca