Version 5.4
Mus musculus Protein: Thra
Summary
InnateDB Protein IDBP-539198.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Thra
Protein Name thyroid hormone receptor alpha
Synonyms 6430529J03Rik; AW259572; Erba; Nr1a1; Rvr; T3R[a]; T3Ralpha; Thra1; Thra2;
Species Mus musculus
Ensembl Protein ENSMUSP00000123056
InnateDB Gene IDBG-210748 (Thra)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 61 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 61 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002153 steroid receptor RNA activator RNA binding
GO:0003727 single-stranded RNA binding
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0004887 thyroid hormone receptor activity
GO:0005515 protein binding
GO:0017025 TBP-class protein binding
GO:0019904 protein domain specific binding
GO:0031490 chromatin DNA binding
GO:0032403 protein complex binding
GO:0070324 thyroid hormone binding
Biological Process
GO:0001502 cartilage condensation
GO:0001503 ossification
GO:0002155 regulation of thyroid hormone mediated signaling pathway
GO:0006366 transcription from RNA polymerase II promoter
GO:0007611 learning or memory
GO:0008016 regulation of heart contraction
GO:0008050 female courtship behavior
GO:0009409 response to cold
GO:0009755 hormone-mediated signaling pathway
GO:0009887 organ morphogenesis
GO:0010831 positive regulation of myotube differentiation
GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly
GO:0030218 erythrocyte differentiation
GO:0030522 intracellular receptor signaling pathway
GO:0030878 thyroid gland development
GO:0033032 regulation of myeloid cell apoptotic process
GO:0042994 cytoplasmic sequestering of transcription factor
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045925 positive regulation of female receptivity
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050994 regulation of lipid catabolic process
GO:0060509 Type I pneumocyte differentiation
GO:2000143 negative regulation of DNA-dependent transcription, initiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Protein Structure and Domains
PDB ID MGI:98742
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A3KFN7
UniProt Splice Variant
Entrez Gene 21833
UniGene Mm.451591
RefSeq
MGI ID
MGI Symbol Thra
OMIM
CCDS
HPRD
IMGT
EMBL AL590963
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca