InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Selp

Summary

InnateDB Protein

IDBP-539214.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Selp

Protein Name

selectin, platelet

Synonyms

CD62P; GMP-140; Grmp; LECAM3; PADGEM;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000123924

InnateDB Gene

IDBG-202346 (Selp)

Protein Structure

UniProt Annotation

Function

Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1. {ECO:0000269PubMed:12370362}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001530	lipopolysaccharide binding
GO:0001948	glycoprotein binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0030246	carbohydrate binding
GO:0033691	sialic acid binding
GO:0042806	fucose binding
GO:0048306	calcium-dependent protein binding
GO:0070492	oligosaccharide binding

Biological Process

GO:0002687	positive regulation of leukocyte migration
GO:0006954	inflammatory response
GO:0007157	heterophilic cell-cell adhesion
GO:0007159	leukocyte cell-cell adhesion
GO:0010572	positive regulation of platelet activation
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0033623	regulation of integrin activation
GO:0050900	leukocyte migration
GO:0050901	leukocyte tethering or rolling
GO:0071354	cellular response to interleukin-6

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031092	platelet alpha granule membrane

Protein Structure and Domains

PDB ID

MGI:98280

InterPro

IPR000436 Sushi/SCR/CCP
IPR000742 Epidermal growth factor-like domain
IPR001304 C-type lectin
IPR001881 EGF-like calcium-binding domain
IPR002396 Selectin superfamily
IPR013111 EGF-like domain, extracellular
IPR016187 C-type lectin fold

PFAM

PF00084
PF00008
PF00059
PF07645
PF07974

PRINTS

PR00343

PIRSF

SMART

SM00032
SM00181
SM00034
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt