Version 5.4
Mus musculus Protein: Ptgr2
Summary
InnateDB Protein IDBP-539352.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ptgr2
Protein Name prostaglandin reductase 2
Synonyms 1810016I24Rik; 9130222H03Rik; 9630002F03Rik; AI838763; B830026H24Rik; PGR-2; PRG-2; Zadh1;
Species Mus musculus
Ensembl Protein ENSMUSP00000119981
InnateDB Gene IDBG-156341 (Ptgr2)
Protein Structure
UniProt Annotation
Function Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto- PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation. {ECO:0000269PubMed:17449869}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed with highest levels in adipose tissues. {ECO:0000269PubMed:17449869}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0036132 13-prostaglandin reductase activity
GO:0047522 15-oxoprostaglandin 13-oxidase activity
Biological Process
GO:0006693 prostaglandin metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol
Protein Structure and Domains
PDB ID MGI:1916372
InterPro IPR011032 GroES (chaperonin 10)-like
IPR013149 Alcohol dehydrogenase, C-terminal
PFAM PF00107
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8VDQ1
PhosphoSite PhosphoSite-Q8VDQ1
TrEMBL
UniProt Splice Variant
Entrez Gene 77219
UniGene Mm.475248
RefSeq
MGI ID 2ZB3
MGI Symbol Ptgr2
OMIM
CCDS CCDS36490
HPRD
IMGT
EMBL AK021033 AK036168 AK145232 AK159932 AK168895 BC021466
GenPept AAH21466 BAB32284 BAC29329 BAE26315 BAE35493 BAE40712

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca