InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Syvn1

Summary

InnateDB Protein

IDBP-539599.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Syvn1

Protein Name

synovial apoptosis inhibitor 1, synoviolin

Synonyms

1200010C09Rik; AW211966; C85322; D530017H19Rik; Hrd1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000114843

InnateDB Gene

IDBG-134090 (Syvn1)

Protein Structure

UniProt Annotation

Function

Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis. Required for embryogenesis. {ECO:0000269PubMed:12975321, ECO:0000269PubMed:15611074, ECO:0000269PubMed:17170702}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:17059562}; Multi-pass membrane protein {ECO:0000269PubMed:17059562}.

Disease Associations

Tissue Specificity

Ubiquitously expressed, with highest levels in bone, spleen, lung and testis. In the brain, present in neurons but not in glial cells. Up-regulated in synovial tissues from mice with collagen-induced arthritis (at protein level). {ECO:0000269PubMed:12975321, ECO:0000269PubMed:17059562}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	46 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016881	acid-amino acid ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006986	response to unfolded protein
GO:0016567	protein ubiquitination
GO:0018279	protein N-linked glycosylation via asparagine
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:1902236	negative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0005634	nucleus
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane