InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Syvn1

Summary

InnateDB Gene

IDBG-134090.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Syvn1

Gene Name

synovial apoptosis inhibitor 1, synoviolin

Synonyms

1200010C09Rik; AW211966; C85322; D530017H19Rik; Hrd1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024807

Encoded Proteins

IDBP-134094

synovial apoptosis inhibitor 1, synoviolin

IDBP-539599

synovial apoptosis inhibitor 1, synoviolin

IDBP-537546

synovial apoptosis inhibitor 1, synoviolin

IDBP-537652

synovial apoptosis inhibitor 1, synoviolin

IDBP-534479

synovial apoptosis inhibitor 1, synoviolin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162298:
This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. Sequence analysis identified two transcript variants that encode different isoforms. [provided by RefSeq, May 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:6046576-6053712

Strand

Forward strand

Band

Transcripts

ENSMUST00000025723	ENSMUSP00000025723
ENSMUST00000138532	ENSMUSP00000114843
ENSMUST00000129081	ENSMUSP00000118698
ENSMUST00000156550	ENSMUSP00000121885
ENSMUST00000142101
ENSMUST00000134667	ENSMUSP00000114960
ENSMUST00000144328

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	46 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016881	acid-amino acid ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006986	response to unfolded protein
GO:0016567	protein ubiquitination
GO:0018279	protein N-linked glycosylation via asparagine
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:1902236	negative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0005634	nucleus
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane