Version 5.4
Mus musculus Protein: Lsm11
Summary
InnateDB Protein IDBP-539751.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lsm11
Protein Name U7 snRNP-specific Sm-like protein LSM11
Synonyms 2210404M20Rik; AV079530;
Species Mus musculus
Ensembl Protein ENSMUSP00000117531
InnateDB Gene IDBG-164855 (Lsm11)
Protein Structure
UniProt Annotation
Function Component of the U7 snRNP complex that is involved in the histone 3'-end pre-mRNA processing. Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to the Sm-binding site of U7 snRNA. {ECO:0000269PubMed:12975319, ECO:0000269PubMed:15824063, ECO:0000269PubMed:16914750}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0071209 U7 snRNA binding
Biological Process
GO:0000084 mitotic S phase
GO:0006398 histone mRNA 3'-end processing
Cellular Component
GO:0005634 nucleus
GO:0005683 U7 snRNP
GO:0071204 histone pre-mRNA 3'end processing complex
Protein Structure and Domains
PDB ID MGI:1919540
InterPro IPR001163 Ribonucleoprotein LSM domain
IPR006649 Ribonucleoprotein LSM domain, eukaryotic/archaea-type
IPR010920 Like-Sm (LSM) domain
PFAM PF01423
PRINTS
PIRSF
SMART SM00651
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BUV6
PhosphoSite PhosphoSite-Q8BUV6
TrEMBL Q9CVB3
UniProt Splice Variant
Entrez Gene 72290
UniGene Mm.455600
RefSeq NP_082461
MGI ID
MGI Symbol Lsm11
OMIM
CCDS CCDS36131
HPRD
IMGT
EMBL AF514309 AK008830 AK082292 AK143661 BC094286 CH466575
GenPept AAH94286 AAQ08118 BAB25917 BAC38456 BAE25483 EDL33832

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca