InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Itgb1

Summary

InnateDB Protein

IDBP-539773.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Itgb1

Protein Name

integrin beta 1 (fibronectin receptor beta)

Synonyms

4633401G24Rik; AA409975; AA960159; CD29; ENSMUSG00000051907; Fnrb; Gm9863; gpIIa;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000120026

InnateDB Gene

IDBG-201159 (Itgb1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 88 interaction(s) predicted by orthology.

Experimentally validated
Total	46 [view]
Protein-Protein	46 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	88 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0043236	laminin binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0001701	in utero embryonic development
GO:0001708	cell fate specification
GO:0002042	cell migration involved in sprouting angiogenesis
GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007275	multicellular organismal development
GO:0008284	positive regulation of cell proliferation
GO:0008354	germ cell migration
GO:0016477	cell migration
GO:0021943	formation of radial glial scaffolds
GO:0031175	neuron projection development
GO:0045214	sarcomere organization
GO:0045596	negative regulation of cell differentiation
GO:0048675	axon extension
GO:0048738	cardiac muscle tissue development
GO:0051726	regulation of cell cycle
GO:0055007	cardiac muscle cell differentiation

Cellular Component

GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0014704	intercalated disc
GO:0016020	membrane
GO:0031594	neuromuscular junction
GO:0034677	integrin alpha7-beta1 complex
GO:0042383	sarcolemma
GO:0043235	receptor complex
GO:0045202	synapse

Protein Structure and Domains

PDB ID

MGI:96610

InterPro

IPR016201 Plexin-like fold

PFAM

PRINTS

PIRSF

SMART

SM00423

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

D6RJL5

UniProt Splice Variant

Entrez Gene

16412

UniGene

Mm.466307

RefSeq

MGI ID

MGI Symbol

Itgb1

OMIM

CCDS

HPRD

IMGT

EMBL

AC156608

GenPept