Version 5.4
Homo sapiens Protein: SLC22A11
Summary
InnateDB Protein IDBP-53984.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC22A11
Protein Name solute carrier family 22 (organic anion/urate transporter), member 11
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000366809
InnateDB Gene IDBG-53978 (SLC22A11)
Protein Structure
UniProt Annotation
Function Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds. {ECO:0000269PubMed:10660625, ECO:0000269PubMed:15102942, ECO:0000269PubMed:15291761}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:15291761, ECO:0000269PubMed:15576633}; Multi-pass membrane protein {ECO:0000269PubMed:15291761, ECO:0000269PubMed:15576633}.
Disease Associations
Tissue Specificity Detected in placenta and kidney. {ECO:0000269PubMed:10660625}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005452 inorganic anion exchanger activity
GO:0005515 protein binding
GO:0008514 organic anion transmembrane transporter activity
GO:0015347 sodium-independent organic anion transmembrane transporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0015711 organic anion transport
GO:0046415 urate metabolic process
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR005828 General substrate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
PFAM PF00083
PF07690
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NSA0
PhosphoSite PhosphoSite-Q9NSA0
TrEMBL
UniProt Splice Variant
Entrez Gene 55867
UniGene Hs.657603
RefSeq
HUGO HGNC:18120
OMIM 607097
CCDS
HPRD 06161
IMGT
EMBL AB026116 AC044790 AK075224 AK129930 AK222869 AK290791 BC034384 CH471076
GenPept AAH34384 AAK68155 BAA95316 BAC11483 BAC85252 BAD96589 BAF83480 EAW74269

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca