InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prdx2

Summary

InnateDB Protein

IDBP-539848.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prdx2

Protein Name

peroxiredoxin 2

Synonyms

AL022839; Band-8; NkefB; PRP; PrxII; Tdpx1; TDX1; Torin; TPx; TPx-B; TR; TSA;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000122694

InnateDB Gene

IDBG-175630 (Prdx2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	18 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	48 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004601	peroxidase activity
GO:0005515	protein binding
GO:0008379	thioredoxin peroxidase activity
GO:0008430	selenium binding
GO:0016209	antioxidant activity
GO:0016491	oxidoreductase activity

Biological Process

GO:0000187	activation of MAPK activity
GO:0002536	respiratory burst involved in inflammatory response
GO:0006979	response to oxidative stress
GO:0010310	regulation of hydrogen peroxide metabolic process
GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032496	response to lipopolysaccharide
GO:0042098	T cell proliferation
GO:0042743	hydrogen peroxide metabolic process
GO:0042744	hydrogen peroxide catabolic process
GO:0045581	negative regulation of T cell differentiation
GO:0048538	thymus development
GO:0048872	homeostasis of number of cells
GO:0055114	oxidation-reduction process
GO:2000378	negative regulation of reactive oxygen species metabolic process
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005739

mitochondrion

Protein Structure and Domains

PDB ID

MGI:109486

InterPro

IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
IPR012336 Thioredoxin-like fold
IPR013740 Redoxin

PFAM

PF00578
PF13098
PF13192
PF13462
PF13905
PF08534

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

D3Z4A4

UniProt Splice Variant

Entrez Gene

21672

UniGene

Mm.389169

RefSeq

MGI ID

MGI Symbol

Prdx2

OMIM

CCDS

HPRD

IMGT

EMBL

AC163703

GenPept