Version 5.4
Mus musculus Protein: Brd4
Summary
InnateDB Protein IDBP-540016.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Brd4
Protein Name bromodomain containing 4
Synonyms Brd5; HUNK1; MCAP; WI-11513;
Species Mus musculus
Ensembl Protein ENSMUSP00000115163
InnateDB Gene IDBG-165269 (Brd4)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 9 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 40 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002039 p53 binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0070577 lysine-acetylated histone binding
Biological Process
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0001833 inner cell mass cell proliferation
GO:0006338 chromatin remodeling
GO:0006468 protein phosphorylation
GO:0007059 chromosome segregation
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043388 positive regulation of DNA binding
GO:0043983 histone H4-K12 acetylation
GO:0044154 histone H3-K14 acetylation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050727 regulation of inflammatory response
GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain
GO:2000002 negative regulation of DNA damage checkpoint
Cellular Component
GO:0000790 nuclear chromatin
GO:0000794 condensed nuclear chromosome
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0008024 positive transcription elongation factor complex b
Protein Structure and Domains
PDB ID MGI:1888520
InterPro IPR001487 Bromodomain
PFAM PF00439
PRINTS PR00503
PIRSF
SMART SM00297
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q3U3Z2
UniProt Splice Variant
Entrez Gene 57261
UniGene Mm.395253
RefSeq
MGI ID
MGI Symbol Brd4
OMIM
CCDS
HPRD
IMGT
EMBL AK154514 CT033751 CT033755
GenPept BAE32643

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca