InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hand1

Summary

InnateDB Protein

IDBP-540189.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hand1

Protein Name

heart and neural crest derivatives expressed transcript 1

Synonyms

bHLHa27; eHAND; Ehand1; Hxt; Th1; Thing1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000124951

InnateDB Gene

IDBG-175912 (Hand1)

Protein Structure

UniProt Annotation

Function

Transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes. Binds the DNA sequence 5'- NRTCTG-3' (non-canonical E-box). {ECO:0000269PubMed:9500551}.

Subcellular Localization

Nucleus, nucleoplasm {ECO:0000269PubMed:17891141}. Nucleus, nucleolus {ECO:0000269PubMed:17891141}. Note=Interaction with MDFIC sequesters it into the nucleolus, preventing the transcription factor activity. Phosphorylation by PLK4 disrupts the interaction with MDFIC and releases it from the nucleolus, leading to transcription factor activity.

Disease Associations

Tissue Specificity

Smooth muscle cells of the gut and adrenal tissue.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019899	enzyme binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0043425	bHLH transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001525	angiogenesis
GO:0001701	in utero embryonic development
GO:0001707	mesoderm formation
GO:0001709	cell fate determination
GO:0001829	trophectodermal cell differentiation
GO:0001947	heart looping
GO:0003007	heart morphogenesis
GO:0003144	embryonic heart tube formation
GO:0003218	cardiac left ventricle formation
GO:0003219	cardiac right ventricle formation
GO:0006366	transcription from RNA polymerase II promoter
GO:0007507	heart development
GO:0030154	cell differentiation
GO:0035050	embryonic heart tube development
GO:0042475	odontogenesis of dentin-containing tooth
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0055010	ventricular cardiac muscle tissue morphogenesis
GO:0060411	cardiac septum morphogenesis
GO:0060485	mesenchyme development
GO:0060536	cartilage morphogenesis
GO:0060707	trophoblast giant cell differentiation
GO:0061371	determination of heart left/right asymmetry