InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lpin2

Summary

InnateDB Protein

IDBP-540390.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lpin2

Protein Name

lipin 2

Synonyms

2610511G02Rik; AI481352; AW742896;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000119282

InnateDB Gene

IDBG-196742 (Lpin2)

Protein Structure

UniProt Annotation

Function

Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism. {ECO:0000269PubMed:19136718, ECO:0000269PubMed:19717560}.

Subcellular Localization

Nucleus. Cytoplasm, cytosol. Endoplasmic reticulum membrane. Note=Translocates from cytosol to endoplasmic reticulum membrane with increasing levels of oleate.

Disease Associations

Tissue Specificity

Expressed at high level in liver and to some extend in lung, kidney, placenta, spleen, thymus, lymph node, prostate, testes, small intestine, and colon. Expressed also in circulating red blood cells and site of lymphopoiesis. {ECO:0000269PubMed:17158099, ECO:0000269PubMed:19717560}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0008195	phosphatidate phosphatase activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006629	lipid metabolic process
GO:0006631	fatty acid metabolic process
GO:0016311	dephosphorylation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter