InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dsp

Summary

InnateDB Protein

IDBP-540495.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dsp

Protein Name

desmoplakin

Synonyms

2300002E22Rik; 5730453H04Rik; AA407887; AA407888; AW109828; DP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000115062

InnateDB Gene

IDBG-145817 (Dsp)

Protein Structure

UniProt Annotation

Function

Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.

Subcellular Localization

Cell junction, desmosome {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Innermost portion of the desmosomal plaque. Colocalizes with epidermal KRT5-KRT14 and simple KRT8-KRT18 keratins and VIM intermediate filaments network (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 55 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	55 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005080	protein kinase C binding
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0030674	protein binding, bridging
GO:0044822	poly(A) RNA binding
GO:0050839	cell adhesion molecule binding
GO:0097110	scaffold protein binding

Biological Process

GO:0002934	desmosome organization
GO:0003223	ventricular compact myocardium morphogenesis
GO:0016337	single organismal cell-cell adhesion
GO:0018149	peptide cross-linking
GO:0030216	keratinocyte differentiation
GO:0034332	adherens junction organization
GO:0042060	wound healing
GO:0043588	skin development
GO:0045104	intermediate filament cytoskeleton organization
GO:0045109	intermediate filament organization
GO:0071896	protein localization to adherens junction
GO:0086005	ventricular cardiac muscle cell action potential
GO:0086069	bundle of His cell to Purkinje myocyte communication
GO:0086091	regulation of heart rate by cardiac conduction

Cellular Component

GO:0001533	cornified envelope
GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005856	cytoskeleton
GO:0005882	intermediate filament
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005916	fascia adherens
GO:0014704	intercalated disc
GO:0016020	membrane
GO:0016323	basolateral plasma membrane
GO:0030057	desmosome
GO:0070062	extracellular vesicular exosome