InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Map2k3

Summary

InnateDB Protein

IDBP-540518.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Map2k3

Protein Name

mitogen-activated protein kinase kinase 3

Synonyms

AW212142; MEK3; MKK3; mMKK3b; Prkmk3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000114430

InnateDB Gene

IDBG-182020 (Map2k3)

Protein Structure

UniProt Annotation

Function

Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38 (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004708	MAP kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding

Biological Process

GO:0000165	MAPK cascade
GO:0000187	activation of MAPK activity
GO:0006468	protein phosphorylation
GO:0006954	inflammatory response
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0042035	regulation of cytokine biosynthetic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060048	cardiac muscle contraction

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

MGI:1346868

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR011009 Protein kinase-like domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O09110

PhosphoSite

PhosphoSite-O09110

TrEMBL

UniProt Splice Variant

Entrez Gene

26397

UniGene

Mm.18494

RefSeq

MGI ID

1LEZ

MGI Symbol

Map2k3

OMIM

CCDS

HPRD

IMGT

EMBL

AK008141 AK011002 BC007467 D87115 X93150

GenPept

AAH07467 BAA13247 BAB25489 BAB27321 CAA63649