Version 5.4
Mus musculus Protein: Gnao1
Summary
InnateDB Protein IDBP-540529.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gnao1
Protein Name guanine nucleotide binding protein, alpha O
Synonyms alphaO; AW050213; Galphao; Gnao;
Species Mus musculus
Ensembl Protein ENSMUSP00000119220
InnateDB Gene IDBG-181138 (Gnao1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0004871 signal transducer activity
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0031683 G-protein beta/gamma-subunit complex binding
GO:0031821 G-protein coupled serotonin receptor binding
GO:0031852 mu-type opioid receptor binding
GO:0032794 GTPase activating protein binding
GO:0051430 corticotropin-releasing hormone receptor 1 binding
Biological Process
GO:0006184 GTP catabolic process
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007212 dopamine receptor signaling pathway
GO:0007568 aging
GO:0007626 locomotory behavior
GO:0008016 regulation of heart contraction
GO:0009987 cellular process
GO:0030900 forebrain development
GO:0031175 neuron projection development
GO:0034097 response to cytokine
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0043278 response to morphine
GO:0043547 positive regulation of GTPase activity
GO:0051926 negative regulation of calcium ion transport
Cellular Component
GO:0005622 intracellular
GO:0005834 heterotrimeric G-protein complex
GO:0016020 membrane
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0043005 neuron projection
Protein Structure and Domains
PDB ID MGI:95775
InterPro IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
IPR001408 G-protein alpha subunit, group I
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR011025 G protein alpha subunit, helical insertion
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00503
PF00025
PRINTS PR00318
PR00441
PR00328
PIRSF
SMART SM00275
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL D3Z2M7
UniProt Splice Variant
Entrez Gene 14681
UniGene Mm.487013
RefSeq
MGI ID
MGI Symbol Gnao1
OMIM
CCDS
HPRD
IMGT
EMBL AC102398 AC138118
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca