InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ube2j1

Summary

InnateDB Protein

IDBP-540544.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ube2j1

Protein Name

ubiquitin-conjugating enzyme E2, J1

Synonyms

0710008M05Rik; 1110030I22Rik; Ncube; NCUBE-1; Ncube1; Ubc6p;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000118333

InnateDB Gene

IDBG-134302 (Ube2j1)

Protein Structure

UniProt Annotation

Function

Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) (By similarity). {ECO:0000255PROSITE-ProRule:PRU00388}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005524	ATP binding
GO:0016881	acid-amino acid ligase activity

Biological Process

GO:0016567	protein ubiquitination
GO:0018279	protein N-linked glycosylation via asparagine
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process