InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Plcb4

Summary

InnateDB Protein

IDBP-540576.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plcb4

Protein Name

phospholipase C, beta 4

Synonyms

A930039J07Rik; AI854601; C230058B11Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000117638

InnateDB Gene

IDBG-207722 (Plcb4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004871	signal transducer activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008081	phosphoric diester hydrolase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0007165	signal transduction
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005634	nucleus
GO:0005790	smooth endoplasmic reticulum
GO:0014069	postsynaptic density
GO:0030425	dendrite

Protein Structure and Domains

PDB ID

MGI:107464

InterPro

IPR000008 C2 domain
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001192 Phosphoinositide phospholipase C family
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain

PFAM

PF00168
PF00388
PF00387
PF09279

PRINTS

PR00360
PR00390

PIRSF

SMART

SM00239
SM00148
SM00149

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt