Version 5.4
Mus musculus Protein: Cacna1s
Summary
InnateDB Protein IDBP-540723.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cacna1s
Protein Name calcium channel, voltage-dependent, L type, alpha 1S subunit
Synonyms AW493108; Cav1.1; Cchl1a3; fmd; mdg; sj;
Species Mus musculus
Ensembl Protein ENSMUSP00000125262
InnateDB Gene IDBG-195266 (Cacna1s)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0008331 high voltage-gated calcium channel activity
Biological Process
GO:0001501 skeletal system development
GO:0002074 extraocular skeletal muscle development
GO:0006811 ion transport
GO:0006816 calcium ion transport
GO:0006936 muscle contraction
GO:0006941 striated muscle contraction
GO:0007029 endoplasmic reticulum organization
GO:0007519 skeletal muscle tissue development
GO:0007520 myoblast fusion
GO:0007528 neuromuscular junction development
GO:0034765 regulation of ion transmembrane transport
GO:0043501 skeletal muscle adaptation
GO:0048741 skeletal muscle fiber development
GO:0055001 muscle cell development
GO:0055085 transmembrane transport
GO:0070509 calcium ion import
GO:0086010 membrane depolarization during action potential
Cellular Component
GO:0005891 voltage-gated calcium channel complex
GO:0016020 membrane
GO:0016529 sarcoplasmic reticulum
GO:0030315 T-tubule
Protein Structure and Domains
PDB ID MGI:88294
InterPro IPR002077 Voltage-dependent calcium channel, alpha-1 subunit
IPR005446 Voltage-dependent calcium channel, L-type, alpha-1 subunit
IPR005450 Voltage-dependent calcium channel, L-type, alpha-1S subunit
IPR005821 Ion transport domain
IPR013122 Polycystin cation channel, PKD1/PKD2
IPR014873 Voltage-dependent calcium channel, alpha-1 subunit, IQ domain
PFAM PF00520
PF08016
PF08763
PRINTS PR00167
PR01630
PR01634
PIRSF
SMART SM01062
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F7CNJ1
UniProt Splice Variant
Entrez Gene 12292
UniGene Mm.4418
RefSeq
MGI ID
MGI Symbol Cacna1s
OMIM
CCDS
HPRD
IMGT
EMBL AC124375 AC124550
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca