InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cacna1s

Summary

InnateDB Gene

IDBG-195266.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cacna1s

Gene Name

calcium channel, voltage-dependent, L type, alpha 1S subunit

Synonyms

AW493108; Cav1.1; Cchl1a3; fmd; mdg; sj

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026407

Encoded Proteins

IDBP-256769

calcium channel, voltage-dependent, L type, alpha 1S subunit

IDBP-256771

calcium channel, voltage-dependent, L type, alpha 1S subunit

IDBP-531727

calcium channel, voltage-dependent, L type, alpha 1S subunit

IDBP-540723

calcium channel, voltage-dependent, L type, alpha 1S subunit

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000081248:
This gene encodes one of the five subunits of the slowly inactivating L-type voltage-dependent calcium channel in skeletal muscle cells. Mutations in this gene have been associated with hypokalemic periodic paralysis, thyrotoxic periodic paralysis and malignant hyperthermia susceptibility. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:136052750-136119822

Strand

Forward strand

Band

Transcripts

ENSMUST00000112068	ENSMUSP00000107699
ENSMUST00000112064	ENSMUSP00000107695
ENSMUST00000160641	ENSMUSP00000125278
ENSMUST00000161865	ENSMUSP00000125262
ENSMUST00000161700
ENSMUST00000159106

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005245	voltage-gated calcium channel activity
GO:0008331	high voltage-gated calcium channel activity

Biological Process

GO:0001501	skeletal system development
GO:0002074	extraocular skeletal muscle development
GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0006936	muscle contraction
GO:0006941	striated muscle contraction
GO:0007029	endoplasmic reticulum organization
GO:0007519	skeletal muscle tissue development
GO:0007520	myoblast fusion
GO:0007528	neuromuscular junction development
GO:0034765	regulation of ion transmembrane transport
GO:0043501	skeletal muscle adaptation
GO:0048741	skeletal muscle fiber development
GO:0055001	muscle cell development
GO:0055085	transmembrane transport
GO:0070509	calcium ion import
GO:0086010	membrane depolarization during action potential

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005891	voltage-gated calcium channel complex
GO:0016020	membrane
GO:0016529	sarcoplasmic reticulum
GO:0030315	T-tubule
GO:0031674	I band