Version 5.4
Mus musculus Protein: Apoc3
Summary
InnateDB Protein IDBP-540879.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Apoc3
Protein Name apolipoprotein C-III
Synonyms apo-CIII; apoC-III;
Species Mus musculus
Ensembl Protein ENSMUSP00000115025
InnateDB Gene IDBG-161220 (Apoc3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005543 phospholipid binding
GO:0008289 lipid binding
GO:0055102 lipase inhibitor activity
GO:0070653 high-density lipoprotein particle receptor binding
Biological Process
GO:0006641 triglyceride metabolic process
GO:0006642 triglyceride mobilization
GO:0006869 lipid transport
GO:0006954 inflammatory response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007584 response to nutrient
GO:0008203 cholesterol metabolic process
GO:0010897 negative regulation of triglyceride catabolic process
GO:0010916 negative regulation of very-low-density lipoprotein particle clearance
GO:0010987 negative regulation of high-density lipoprotein particle clearance
GO:0010989 negative regulation of low-density lipoprotein particle clearance
GO:0019433 triglyceride catabolic process
GO:0032489 regulation of Cdc42 protein signal transduction
GO:0033344 cholesterol efflux
GO:0033700 phospholipid efflux
GO:0034375 high-density lipoprotein particle remodeling
GO:0034382 chylomicron remnant clearance
GO:0042157 lipoprotein metabolic process
GO:0042493 response to drug
GO:0042632 cholesterol homeostasis
GO:0042953 lipoprotein transport
GO:0043434 response to peptide hormone
GO:0045717 negative regulation of fatty acid biosynthetic process
GO:0048261 negative regulation of receptor-mediated endocytosis
GO:0051005 negative regulation of lipoprotein lipase activity
GO:0060621 negative regulation of cholesterol import
GO:0070328 triglyceride homeostasis
GO:0071333 cellular response to glucose stimulus
Cellular Component
GO:0005576 extracellular region
GO:0034361 very-low-density lipoprotein particle
GO:0034363 intermediate-density lipoprotein particle
GO:0034366 spherical high-density lipoprotein particle
GO:0042627 chylomicron
Protein Structure and Domains
PDB ID MGI:88055
InterPro IPR008403 Apolipoprotein CIII
PFAM PF05778
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL D3YXN8
UniProt Splice Variant
Entrez Gene 11814
UniGene
RefSeq
MGI ID
MGI Symbol Apoc3
OMIM
CCDS
HPRD
IMGT
EMBL AC116503
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca