InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Apoc3

Summary

InnateDB Gene

IDBG-161220.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Apoc3

Gene Name

apolipoprotein C-III

Synonyms

apo-CIII; apoC-III

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032081

Encoded Proteins

IDBP-161222

apolipoprotein C-III

IDBP-401166

apolipoprotein C-III

IDBP-401165

apolipoprotein C-III

IDBP-540879

apolipoprotein C-III

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes an apolipoprotein which is the major protein component of very-low-density lipoproteins (VLDL) and a minor component of high-density lipoproteins (HDL). The encoded protein is thought to regulate the metabolism of triglyceride-rich lipoproteins and play a role in lipid storage and the mobilization of fat cells. This gene is clustered with three other apolipoprotein genes on chromosome 9 and is associated with coronary disease. Mice lacking this gene have lower levels of total cholesterol in the plasma. Mutations in the human genes causes hyperalphalipoproteinemia 2, a disorder of lipid metabolism which results in a favorable lipid profile (lower LDL-cholesterol, higher HDL-cholesterol and lower levels of serum triglycerides when fasting and after a meal). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:46232933-46235636

Strand

Reverse strand

Band

A5.2

Transcripts

ENSMUST00000034586	ENSMUSP00000034586
ENSMUST00000121916	ENSMUSP00000113126
ENSMUST00000118649	ENSMUSP00000113058
ENSMUST00000145672	ENSMUSP00000115025

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005543	phospholipid binding
GO:0008289	lipid binding
GO:0030234	enzyme regulator activity
GO:0055102	lipase inhibitor activity
GO:0070653	high-density lipoprotein particle receptor binding

Biological Process

GO:0006641	triglyceride metabolic process
GO:0006642	triglyceride mobilization
GO:0006869	lipid transport
GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007584	response to nutrient
GO:0008203	cholesterol metabolic process
GO:0010897	negative regulation of triglyceride catabolic process
GO:0010916	negative regulation of very-low-density lipoprotein particle clearance
GO:0010987	negative regulation of high-density lipoprotein particle clearance
GO:0010989	negative regulation of low-density lipoprotein particle clearance
GO:0019433	triglyceride catabolic process
GO:0032489	regulation of Cdc42 protein signal transduction
GO:0033344	cholesterol efflux
GO:0033700	phospholipid efflux
GO:0034375	high-density lipoprotein particle remodeling
GO:0034382	chylomicron remnant clearance
GO:0042157	lipoprotein metabolic process
GO:0042493	response to drug
GO:0042632	cholesterol homeostasis
GO:0042953	lipoprotein transport
GO:0043434	response to peptide hormone
GO:0045717	negative regulation of fatty acid biosynthetic process
GO:0045833	negative regulation of lipid metabolic process
GO:0048261	negative regulation of receptor-mediated endocytosis
GO:0050995	negative regulation of lipid catabolic process
GO:0051005	negative regulation of lipoprotein lipase activity
GO:0060621	negative regulation of cholesterol import
GO:0070328	triglyceride homeostasis
GO:0071333	cellular response to glucose stimulus

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005829	cytosol
GO:0034361	very-low-density lipoprotein particle
GO:0034363	intermediate-density lipoprotein particle
GO:0034366	spherical high-density lipoprotein particle
GO:0042627	chylomicron
GO:0070062	extracellular vesicular exosome