InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Abi1

Summary

InnateDB Protein

IDBP-540880.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Abi1

Protein Name

abl-interactor 1

Synonyms

E3B1; NAP1; Ssh3bp1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000117335

InnateDB Gene

IDBG-141468 (Abi1)

Protein Structure

UniProt Annotation

Function

May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. In vitro, at least isoform 2 and isoform 4 suppress the transforming activity of Abelson murine leukemia virus (v-Abl) after overexpression in fibroblasts. May play a role in regulation EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269PubMed:10499589, ECO:0000269PubMed:11526477, ECO:0000269PubMed:12672821, ECO:0000269PubMed:15143189, ECO:0000269PubMed:15558031, ECO:0000269PubMed:7590237}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localized to protruding lamellipodia and filopodia tips. Also localized to neuronal growth cones and synaptosomes. May shuttle from the postsynaptic densities to the nucleus (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed with highest levels in bone marrow, spleen, brain, testes, and embryonic brain. In adult brain prominently expressed in the neocortex, hippocampus and dentate gyrus. {ECO:0000269PubMed:10995551, ECO:0000269PubMed:7590237}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	35 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	60 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030296	protein tyrosine kinase activator activity

Biological Process

GO:0001756	somitogenesis
GO:0006928	cellular component movement
GO:0009987	cellular process
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0035855	megakaryocyte development
GO:0061098	positive regulation of protein tyrosine kinase activity
GO:0072673	lamellipodium morphogenesis

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0014069	postsynaptic density
GO:0030027	lamellipodium
GO:0030054	cell junction
GO:0030175	filopodium
GO:0030426	growth cone
GO:0031252	cell leading edge
GO:0043005	neuron projection
GO:0045211	postsynaptic membrane