InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Abi1

Summary

InnateDB Gene

IDBG-141468.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Abi1

Gene Name

abl-interactor 1

Synonyms

E3B1; NAP1; Ssh3bp1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000058835

Encoded Proteins

IDBP-141470

abl-interactor 1

IDBP-141472

abl-interactor 1

IDBP-141474

abl-interactor 1

IDBP-251535

abl-interactor 1

IDBP-531776

abl-interactor 1

IDBP-540880

abl-interactor 1

IDBP-541085

abl-interactor 1

IDBP-538471

abl-interactor 1

IDBP-542050

abl-interactor 1

IDBP-542493

abl-interactor 1

IDBP-719165

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136754:
This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:22940073-23040241

Strand

Reverse strand

Band

Transcripts

ENSMUST00000091394	ENSMUSP00000088957
ENSMUST00000078977	ENSMUSP00000077997
ENSMUST00000093171	ENSMUSP00000090860
ENSMUST00000114544	ENSMUSP00000110191
ENSMUST00000140164	ENSMUSP00000120462
ENSMUST00000126112	ENSMUSP00000117335
ENSMUST00000149719	ENSMUSP00000120621
ENSMUST00000123948	ENSMUSP00000118491
ENSMUST00000153931	ENSMUSP00000120769
ENSMUST00000139038	ENSMUSP00000116093
ENSMUST00000135308
ENSMUST00000148294
ENSMUST00000156344
ENSMUST00000154162
ENSMUST00000178908	ENSMUSP00000136846

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	35 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	60 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030296	protein tyrosine kinase activator activity
GO:0032403	protein complex binding

Biological Process

GO:0001756	somitogenesis
GO:0006928	cellular component movement
GO:0009987	cellular process
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0035855	megakaryocyte development
GO:0061098	positive regulation of protein tyrosine kinase activity
GO:0072673	lamellipodium morphogenesis

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0014069	postsynaptic density
GO:0030027	lamellipodium
GO:0030054	cell junction
GO:0030175	filopodium
GO:0030426	growth cone
GO:0031209	SCAR complex
GO:0031252	cell leading edge
GO:0043005	neuron projection
GO:0045211	postsynaptic membrane
GO:0070062	extracellular vesicular exosome