InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pfdn2

Summary

InnateDB Protein

IDBP-540898.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pfdn2

Protein Name

prefoldin 2

Synonyms

ESTM27; W48336;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000120106

InnateDB Gene

IDBG-204479 (Pfdn2)

Protein Structure

UniProt Annotation

Function

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding
GO:0051082	unfolded protein binding

Biological Process

GO:0006457

protein folding

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0016272	prefoldin complex
GO:0070062	extracellular vesicular exosome