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InnateDB Protein
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IDBP-541057.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Srebf1
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Protein Name
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sterol regulatory element binding transcription factor 1
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Synonyms
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ADD-1; ADD1; bHLHd1; D630008H06; SREBP-1; SREBP-1a; SREBP-1c; SREBP1; SREBP1c;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000120777
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InnateDB Gene
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IDBG-179865 (Srebf1)
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Protein Structure
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| Function |
Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. Binds to the sterol regulatory element 1 (SRE- 1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC- 3'). Isoform SREBP-1A is much more active than isoform SREBP-1C in stimulating transcription from SRE-1-containing promoters. {ECO:0000269PubMed:11782483, ECO:0000269PubMed:12855691, ECO:0000269PubMed:9329978, ECO:0000269PubMed:9784493}.
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| Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000269PubMed:21459323}; Multi-pass membrane protein {ECO:0000269PubMed:21459323}. Golgi apparatus membrane {ECO:0000269PubMed:21459323}; Multi-pass membrane protein {ECO:0000269PubMed:21459323}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000269PubMed:21459323}; Multi-pass membrane protein {ECO:0000269PubMed:21459323}. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols.Processed sterol regulatory element-binding protein 1: Nucleus.
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| Disease Associations |
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| Tissue Specificity |
Isoform SREBP-1C predominates in liver, adrenal gland, brain and adipose tissue, whereas isoform SREBP-1A predominates in spleen. Isoform SREBP-1A and isoform SREBP-1C are found in kidney, thymus, testis, muscle, jejunum, and ileum.
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
18
[view]
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| Protein-Protein |
12
[view]
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| Protein-DNA |
6
[view]
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
54 [view]
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Molecular Function |
| Accession |
GO Term |
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GO:0046983
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protein dimerization activity
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| Biological Process |
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| Cellular Component |
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| PDB ID |
MGI:107606
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| InterPro |
IPR011598
Myc-type, basic helix-loop-helix (bHLH) domain
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| PFAM |
PF00010
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| PRINTS |
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| PIRSF |
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| SMART |
SM00353
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-Q9WTN3
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
20787
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| UniGene |
Mm.278701
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| RefSeq |
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| MGI ID |
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| MGI Symbol |
Srebf1
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| OMIM |
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
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| GenPept |
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Version 5.4