Version 5.4
Mus musculus Protein: Stag1
Summary
InnateDB Protein IDBP-541063.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Stag1
Protein Name stromal antigen 1
Synonyms AU045003; SA-1; Scc3;
Species Mus musculus
Ensembl Protein ENSMUSP00000116205
InnateDB Gene IDBG-193250 (Stag1)
Protein Structure
UniProt Annotation
Function Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00750}. Chromosome {ECO:0000250}. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0030054 cell junction
Protein Structure and Domains
PDB ID MGI:1098658
InterPro IPR013721 STAG
IPR016024 Armadillo-type fold
PFAM PF08514
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D3E6
PhosphoSite PhosphoSite-Q9D3E6
TrEMBL Q8C818
UniProt Splice Variant
Entrez Gene 20842
UniGene Mm.42135
RefSeq NP_033308
MGI ID
MGI Symbol Stag1
OMIM
CCDS CCDS23441
HPRD
IMGT
EMBL AC115355 AC134825 AC146297 AC147565 AK017978 AK048671 AK086295 BC062954 Z75332
GenPept AAH62954 BAB31022 BAC33417 BAC39645 CAA99733

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca