InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nek6

Summary

InnateDB Protein

IDBP-541163.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nek6

Protein Name

NIMA (never in mitosis gene a)-related expressed kinase 6

Synonyms

1300007C09Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000114376

InnateDB Gene

IDBG-166676 (Nek6)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	47 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004871	signal transducer activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019894	kinesin binding
GO:0019901	protein kinase binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007059	chromosome segregation
GO:0007165	signal transduction
GO:0018105	peptidyl-serine phosphorylation
GO:0030071	regulation of mitotic metaphase/anaphase transition
GO:0031572	G2 DNA damage checkpoint
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0046777	protein autophosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1891638

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR011009 Protein kinase-like domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

A2ATP1

UniProt Splice Variant

Entrez Gene

59126

UniGene

Mm.143818

RefSeq

MGI ID

MGI Symbol

Nek6

OMIM

CCDS

HPRD

IMGT

EMBL

AL928896

GenPept